Anisha Luthra

Publications

Andrew Moorman, Elizabeth Benitez, Francesco Cambulli, Qingwen Jiang, Ahmed Mahmoud, Melissa Lumish, Saskia Hartner, Sasha Balkaran, Jonathan Bermeo, Simran Asawa, Canan Firat, Asha Saxena, Fan Wu, Anisha Luthra, Cassandra Burdziak, Yubin Xie, Valeria Sgambati, Kathleen Luckett, Yanyun Li, Zhifan Yi, Ignas Masilionis, Kevin Soares, Emmanouil Pappou, Rona Yaeger, Karuna Ganesh. Progressive plasticity during colorectal cancer metastasis. Nature. 2025;637:947–954.

Dana Omer, Farheen Shah, Anisha Luthra, Chin-Tung Chen, Christina Lee, Hannah Williams, Henry Walch, Floris Verheij, Roni Rosen, Janet Alvarez, Canan Firat, Georgios Karagkounis, Martin Weiser, Maria Widmar, Iris Wei, Emmanouil Pappou, Garrett Nash, J. Joshua Smith, Walid Chatila, Paul Romesser, Jinru Shia, Philip Paty, Julio Garcia-Aguilar, Francisco Sanchez-Vega. Clinical and Genomic Characterization of Secondary Rectal Cancer After Radiotherapy for Prostate Cancer. JAMA Network Open. 2025;8(3):e251039.

Justin Jee, Angela Rose Brannon, Christopher Fong, Adrian Lee, Lauren Gray, Karl Pichotta, Anisha Luthra, Monica Diosdado, Mohammad Haque, Jiannan Guo, Jennifer Hernandez, Kavita Garg, Andriy Derkach, Clare Wilhelm, Rohan Singh, Maria Arcila, Nick Pavlakis, Stephen Clarke, Sohrab Shah, Pedram Razavi, Jorge Reis-Filho, Marc Ladanyi, Nikolaus Schultz, Jeffrey Zwicker, Michael Berger, Bob Li, Simon Mantha. DNA liquid biopsy-based prediction of cancer-associated venous thromboembolism. Nature Medicine. 2024;30:2499–2507.

Justin Jee, Christopher Fong, Karl Pichotta, Thinh Tran, Anisha Luthra (co-first author), Michele Waters, Chenlian Fu, Mirella Altoe, Si-Yang Liu, Steven Maron, Mehnaj Ahmed, Susie Kim, Mono Pirun, Walid Chatila, Ino de Bruijn, Arfath Pasha, Ritika Kundra, Benjamin Gross, Brooke Mastrogiacomo, Tyler Aprati, David Liu, JianJiong Gao, Marzia Capelletti, Kelly Pekala, MSK Cancer Data Science Initiative Group. Automated real-world data integration improves cancer outcome prediction. Nature. 2024;636:728–736.

Dana M. Omer, Hannah M. Thompson, Floris S. Verheij, Jonathan B. Yuval, Roni Rosen, Nathalie R. A. Beets, Anisha Luthra, Paul B. Romesser, Philip B. Paty, Julio Garcia-Aguilar, Francisco Sanchez-Vega. Rectal Cancer after Prostate Radiation: A Complex and Controversial Disease. Cancers. 2023;15(8):2214.

Anisha Luthra, Brooke Mastrogiacomo, Shaleigh A Smith, Debyani Chakravarty, Nicholas Schultz, Francisco Sanchez-Vega. Computational methods and translational applications for targeted next-generation sequencing platforms. Genes, Chromosomes and Cancer. 2022;61:322–331.

Bastien Nguyen, Christopher Fong, Anisha Luthra, Shaleigh A Smith, Renzo G DiNatale, Subhiksha Nandakumar, Henry Walch, Walid K Chatila, Ramyasree Madupuri, Ritika Kundra, Craig M Bielski, Brooke Mastrogiacomo, Mark T A Donoghue, Adrienne Boire, Sarat Chandarlapaty, Karuna Ganesh, James J Harding, Christine A Iacobuzio-Donahue, Pedram Razavi, Ed Reznik, Charles M Rudin, Dmitriy Zamarin, Wassim Abida, Ghassan K Abou-Alfa, Carol Aghajanian, Andrea Cercek, Ping Chi, Darren Feldman, Alan L Ho, Gopakumar Iyer, Yelena Y Janjigian, Michael Morris, Robert J Motzer, Eileen M O'Reilly, Michael A Postow, Nitya P Raj, Gregory J Riely, Mark E Robson, Jonathan E Rosenberg, Anton Safonov, Alexander N Shoushtari, William Tap, Min Yuen Teo, Anna M Varghese, Martin Voss, Rona Yaeger, Marjorie G Zauderer, Nadeem Abu-Rustum, Julio Garcia-Aguilar, Bernard Bochner, Abraham Hakimi, William R Jarnagin, David R Jones, Daniela Molena, Luc Morris, Eric Rios-Doria, Paul Russo, Samuel Singer, Vivian E Strong, Debyani Chakravarty, Lora H Ellenson, Anuradha Gopalan, Jorge S Reis-Filho, Britta Weigelt, Marc Ladanyi, Mithat Gonen, Sohrab P Shah, Joan Massague, Jianjiong Gao, Ahmet Zehir, Michael F Berger, David B Solit, Samuel F Bakhoum, Francisco Sanchez-Vega, Nikolaus Schultz. Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients. Cell. 2022;185:563–575.

Charlton Tsai, Bastien Nguyen, Anisha Luthra, Joanne F. Chou, Lara Feder, Laura H. Tang, Vivian E. Strong, Daniela Molena, David R. Jones, Daniel G. Coit, David H. Ilson, Geoffrey Y. Ku, Darren Cowzer, John Cadley, Marinela Capanu, Nikolaus Schultz, Kathryn Beal, Nelson S. Moss, Yelena Y. Janjigian, Steven B. Maron. Outcomes and molecular features of brain metastasis in gastroesophageal adenocarcinoma. JAMA Network Open. 2022;5:e2228083.

Walid K Chatila, Jin K Kim, Henry Walch, Michael R Marco, Chin-Tung Chen, Fan Wu, Dana M Omer, Danny N Khalil, Karuna Ganesh, Xuan Qu, Anisha Luthra, Seo-Hyun Choi, Yu-Jui Ho, Ritika Kundra, Katharine I Groves, Oliver S Chow, Andrea Cercek, Martin R Weiser, Maria Widmar, Iris H Wei, Emmanouil P Pappou, Garrett M Nash, Philip B Paty, Qian Shi, Efsevia Vakiani, S Duygu Selcuklu, Mark T A Donoghue, David B Solit, Michael F Berger, Jinru Shia, Raphael Pelossof, Paul B Romesser, Rona Yaeger, J Joshua Smith, Nikolaus Schultz, Francisco Sanchez-Vega, Julio Garcia-Aguilar. Genomic and transcriptomic determinants of response to neoadjuvant therapy in rectal cancer. Nature Medicine. 2022;28:1646–1655.

Benjamin A. Nacev, Francisco Sanchez-Vega, Shaleigh A. Smith, Cristina R. Antonescu, Evan Rosenbaum, Hongyu Shi, Cerise Tang, Nicholas D. Socci, Satshil Rana, Rodrigo Gularte-Mérida, Ahmet Zehir, Mrinal M. Gounder, Timothy G. Bowler, Anisha Luthra, Bhumika Jadeja, Azusa Okada, Jonathan A. Strong, Jake Stoller, Jason E. Chan, Ping Chi, Sandra P. D’Angelo, Mark A. Dickson, Ciara M. Kelly, Mary Louise Keohan, Sujana Movva, Katherine Thornton, Paul A. Meyers, Leonard H. Wexler, Emily K. Slotkin, Julia L. Glade Bender, Neerav N. Shukla, Martee L. Hensley, John H. Healey, Michael P. La Quaglia, Kaled M. Alektiar, Aimee M. Crago, Sam S. Yoon, Brian R. Untch, Sarah Chiang, Narasimhan P. Agaram, Meera R. Hameed, Michael F. Berger, David B. Solit, Nikolaus Schultz, Marc Ladanyi, Samuel Singer & William D. Tap. Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets. Nature Communications. 2022;13(1):3405.

Richard K. G. Do, Kaelan Lupton, Pamela I. Causa Andrieu, Anisha Luthra, Michio Taya, Karen Batch, Huy Nguyen, Prachi Rahurkar, Lior Gazit, Kevin Nicholas, Christopher J. Fong, Natalie Gangai, Nikolaus Schultz, Farhana Zulkernine, Varadan Sevilimedu, Krishna Juluru, Amber Simpson, Hedvig Hricak. Patterns of metastatic disease in patients with cancer derived from natural language processing of structured CT radiology reports over a 10-year period. Radiology. 2021;301:115–122.

Jackson Champer, Zhaoxin Wen, Anisha Luthra, Riona Reeves, Joan Chung, Chen Liu, Yoo Lim Lee, Jingxian Liu, Emily Yang, Philipp W Messer, Andrew G Clark. CRISPR gene drive efficiency and resistance rate is highly heritable with no common genetic loci of large effect. Genetics. 2019;212:333–341.

Jackson Champer, Jingxian Liu, Suh Yeon Oh, Riona Reeves, Anisha Luthra, Nathan Oakes, Andrew G. Clark, and Philipp W. Messer. Reducing resistance allele formation in CRISPR gene drive. PNAS. 2018;115:5522–5527.

Posters and Abstracts

Gerstberger S, Lumish M, Hartner S, Shah F, Choi S, Lum K, Cowley C, Anisha Luthra, Jiang Q, Woo HJ, Mahmoud A, Walch H, Saxena A, Reed TJ, Cercek A, Yaeger R, Cristea I, McPherson A, Sanchez-Vega F, Ganesh K. Abstract 2856: Pks+ E. coli trigger intestinal stem cell plasticity and early onset colorectal cancer. Cancer Research. 2025;85 (8_Supplement_1):2856.

Fong CJ, Pichotta K, Tran T, Waters M, Fu T, Pirun M, Altoe M, Mastrogiacomo B, Anisha Luthra, Ahmed M, Pasha A, Kohli A, Lim R, Pollard T, Moore D, Gross B, Wang A, Chennault C, Kundra R, Madupuri R, de Bruijn I, Lisman A, Chatila WK, Nandakumar S, Begum A, Rose D, Kehl KL, Schrag D, Berger M, Carrot-Zhang J, Razavi P, Li B, Stetson P, Schultz N, Jee J. Abstract 3892: Systematic generation of a clinicogenomic harmonized oncologic real-world dataset (MSK-CHORD). Cancer Research. 2024;84 (6_Supplement):3892.

Tran TN, Fong C, Pichotta K, Anisha Luthra, Shen R, Chen Y, Waters M, Kim S, Riely G, Chakravarty D, Schultz N, Jee J. Abstract 1252: AI-derived predictions improve identification of real-world cancer driver mutations. Cancer Research. 2024;84 (6_Supplement):1252.

Gerstberger S, Lumish M, Hartner S, Shah F, Choi S, Anisha Luthra, Jiang Q, Woo HJ, Mahmoud A, Walch H, Asawa S, Donoghue M, Cercek A, Yaeger R, McPherson A, Sanchez-Vega F, Ganesh K. Abstract 2796: Colibactin mutation signatures are associated with younger age of onset in colorectal cancer. Cancer Research. 2024;84 (6_Supplement):2796.

Tran TN, Fong C, Pichotta K, Anisha Luthra, Shen R, Chen Y, Waters M, Kim S, Berger MF, Riely G, Ladanyi M, Chakravarty D, Schultz N, Jee J. Machine learning predictions improve identification of real-world cancer driver mutations. bioRxiv. 2024;Preprint:https://doi.org/10.1101/2024.03.31.587410.

Dana O, Verheij F, Anisha Luthra, et al.. Oncologic Outcomes in Patients with Radiation Associated Rectal Adenocarcinoma. American Society of Clinical Oncology. 2023;:.

Jee J, Brannon AR, Fong C, Lee A, Gray L, Pichotta K, Anisha Luthra, Diosdado M, Haque M, Guo J, Hernandez J, Garg K, Derkach A, Wilhelm C, Singh R, Arcila ME, Pavlakis N, Clarke S, Shah SP, Razavi P, Reis-Filho J, Ladanyi M, Schultz N, Zwicker JI, Berger MF, Li BT, Mantha S. DNA Liquid Biopsies for Cancer-Associated Venous Thromboembolism Prediction. Blood. 2023;142 (Supplement 1):569.

Agbamu T, Bai X, Walch H, Waters M, Anisha Luthra, Arora K, Fong C, Rose D, Williams H, Berger M, Ganesh K, Garcia-Aguilar J, Schultz N, Yaegar R, Chatila W, Sanchez-Vega F. Abstract C075: Socioeconomic status and genetic ancestry correlate with differences in clinical outcomes for colorectal cancer patients treated at a single tertiary cancer center. Cancer Epidemiol Biomarkers Prev. 2023;32 (12_Supplement):C075.

Luthra A, Pichotta K, Mastrogiacomo B, et al.. AI-assisted clinical data curation to determine genomic biomarkers of cancer metastasis. Cancer Research. 2022;82:1158-1158.

Walch H, Luthra A, Chatila WK, et al.. Integrative analysis of the contribution of genomic and clinical factors to worse clinical outcomes in non-Hispanic Black patients with colorectal cancer. Cancer Research. 2022;82:3634-3634.

Omer DM, Luthra A, Thompson HM, et al.. Abstract A026: Identifying unique genomic and clinical characteristics of radiation-associated rectal cancer. Cancer Research. 2022;82:A026-A026.

Thompson HM, Yuval JB, Luthra A, et al.. Abstract PO-228: Racial disparities and the impact on recurrence and survival in non-metastatic colon cancer patients undergoing colectomy at a comprehensive cancer center. Cancer Epidemiology, Biomarkers & Prevention. 2022;31:PO–228.

Tsai C, Nguyen B, Luthra A, et al.. Brain Metastasis in Gastroesophageal Adenocarcinoma: Outcomes and Molecular Features. American Society of Clinical Oncology. 2022;:.

Walch H, Luthra A, Chatila W, et al.. Abstract A005: Genomic profiling identifies differences in the distribution of APC mutations in non-Hispanic black and non-Hispanic white patients with colorectal cancer. Cancer Research. 2022;82:A005-A005.

Lumish MA, Luthra A, Asawa S, et al.. Colibactin mutation signatures are associated with a distinct colorectal cancer clinicopathologic phenotype. Cancer Research. 2021;81:611-611.

Nguyen B, Fong C, DiNatale R, Luthra A, et al.. Integration of genomic and clinical data from 25,000 patients identifies molecular determinants of metastatic potential and organotropisms. Cancer Research. 2021;81:2834-2834.

Chatila WK, Marco M, Qu X, Walsh HS, Luthra A, et al.. Genomic Characterization of Rectal Cancer and Molecular Determinants of Response to Neoadjuvant Chemoradiotherapy. American Society of Clinical Oncology. 2020;:.

Nguyen B, Fong C, Vega FS, Luthra A, et al.. 37. Spatiotemporal patterns of metastatic spread and survival from MSK-IMPACT, a large-scale prospective clinical sequencing. Cancer Genetics. 2020;244:14.

Fong CJ, Sanchez-Vega F, Ngyuen B, Luthra A, et al.. Integrative analysis of clinical and genomic information identifies predictive markers of metastatic risk. Cancer Research. 2020;80:1109-1109.